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KMID : 0356619950100010035
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Journal of Korean Society of Endocrinology
1995 Volume.10 No. 1 p.35 ~ p.44
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Relationship between Blood Pressure and Insulin Level or Red Cell membrane Na+ Transport in Acromegaly
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김성연
김현규/박경수/조보연/이홍규/고창순
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Abstract
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To test the hypothesis that hyperinsulinemia and/or abnormalities of red cell membrane Na+ transport are concerned in the pathogenesis of hypertension, we investigated the relationship between blood presssure, insulin level and red cell membrane
Na+
transport in patients with acromegaly which is frequently associated with hypertension. Hyperinsulinemia and abnormalities of red cell membrane Na+ transport.
@ES The results were as follows:
@EN 1) BMI and both systolic and diastolic blood pressure were significantly higher in patients with acromegaly than in control subjects
2) Fasting glucose and insulin levels were higher. And both serum glucose and insulin responses after a 75g glucose load were significantly increased in patients with acromegaly as compared with control subjects.
3) Vmax of Na+-Li+ countertransport were significantly higher in patients with acromegaly than in control subjects while red cell Na+ concentration and Vmax of Na+, K+ ATPase were similar in the two groups
4) In multiple stepwise regression analysis, age was directly correlated with both systolic and diastolic blood pressure in acromegaly. On the other hand both insulin level and red cell membrane Na+ transport showed little correlation with
either
systolic or diastolic pressure
5) Prevalence of hypertension in acromegaly was 39%(9 out of 23) and only age except for blood pressure was significantly higher in hypertensive acromegalic patients than in normotensive acromegalic patients while GH level, insulin levels and
red
cell
membrane Na+ transport were similar in the two groups.
These results suggest that hyperinsulinemia or abnormalities of red cell membrane Na+ transport are not causally related to hypertension in patients with acromegaly. (J Kor Soc Endocrinol 10:35~44, 1995).
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KEYWORD
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